Dissociation of Biological Catch-Bond by Periodic Perturbation

Effect of loading conditions on the dissociation behaviour of catch bond clusters.

Under increasing tensile load, the lifetime of a single catch bond counterintuitively increases up to a maximum and then decreases exponentially like a slip bond. So far, the characteristics of single catch bond dissociation have been extensively studied. However, it remains unclear how a cluster of catch bonds behaves under tensile load. We perform computational analysis on the following model...

Controlling Multistability by Small Periodic Perturbation

A small perturbation of any system parameters may not in general create any significant qualitative change in dynamics of a multistable system. However, a slow-periodic modulation with properly adjusted amplitude and frequency can do so. In particular, it can control the number of coexisting attractors. The basic idea in this controlling mechanism is to introduce a collision between an attracto...

Bond dissociation energies

The bond dissociation energy (enthalpy) is also referred to as bond disruption energy, bond energy, bond strength, or binding energy (abbreviation: BDE, BE, or D) . It is defined as the standard enthalpy change of the following fission: R−X → R + X . The BDE, denoted by Do(R−X), is usually derived by the thermochemical equation, Do(R−X) = ∆fH o(R) + ∆fH o(X) – ∆fH o(RX) . The enthalpy of format...

Perturbation of Periodic Boundary-Conditions

Force Modulating Dynamic Disorder: Physical Theory of Catch-slip bond Transitions in Receptor-Ligand Forced Dissociation Experiments

Recently experiments showed that some adhesive receptor-ligand complexes increase their lifetimes when they are stretched by mechanical force, while the force increase beyond some thresholds their lifetimes decrease. Several specific chemical kinetic models have been developed to explain the intriguing transitions from the “catch-bonds” to the “slip-bonds”. In this work we suggest that the coun...